Prognostic Significance and Molecular Features of Signet-Ring Cell and Mucinous Components in Colorectal Carcinoma

Impact of Microsatellite Instability in Signet-Ring Cell and Mucinous Components in Patients With Colorectal Carcinoma

The disease pathogenesis of colorectal cancer (CRC) is influenced by genetic and epigenetic events that occur with tumor initiation and progression [1]. Diagnostic approaches have evolved from relying exclusively on clinical criteria to incorporating pathologic features such as mucinous and signet-ring cell (SRC) carcinomas, PCR-based microsatellite instability (MSI) testing, and immunohistoche...

Prognostic Significance and Molecular Features of Colorectal Mucinous Adenocarcinomas

Mucinous adenocarcinoma (MC) is a special histology subtype of colorectal adenocarcinoma. The survival of MC is controversial and the prognostic biomarkers of MC remain unclear. To analyze prognostic significance and molecular features of colorectal MC. This study included 755,682 and 1001 colorectal cancer (CRC) patients from Surveillance, Epidemiology, and End Results program (SEER, 1973– 201...

Signet-ring cell carcinoma of colorectum – current perspectives and molecular biology REVIEW: Running title: Colorectal signet-ring carcinoma

Correlation of multiple proteins with clinic-pathological features and its prognostic significance in colorectal cancer with signet-ring cell component.

OBJECTIVE Primary colorectal cancer (CRC) with signet-ring cell (SRC) component is a distinct tumor of colon and rectum, and its prognosis is very poor. Reliable markers to predict the poor clinical outcome of this subgroup cancer remains undetermined. Therefore, we perform this study to investigate the prognosis value of seven proteins in CRC with SRC component . PATIENTS AND METHODS This st...

The Characteristics and Prognostic Effect of E-Cadherin Expression in Colorectal Signet Ring Cell Carcinoma

PURPOSE Signet ring cell carcinoma (SRCC) is rare. The aim of this study is to understand the clinicopathological features and identify the possible prognostic factors in colorectal SRCC. METHODS Patients with SRCC who underwent primary lesion resection at Fudan University Shanghai Cancer Center from September 2008 to July 2014 were retrospectively analyzed. Patient's gender, age, tumor locat...